To make a blade in Little Alchemy 2, you will need to combine a few different elements. First, you will need to combine Fire and Air to create Energy. Then, combine Energy and Metal to create a Blade. Alternatively, you can also combine Stone and Fire to create a Metal Blade. Lastly, combine a Metal Blade and Sandpaper to create a Sharp Blade. This Sharp Blade will then be considered a Blade in Little Alchemy 2.